Leonardo J M Carvalho Selected Research

Cerebral Malaria

3/2021	Perillyl alcohol reduces parasite sequestration and cerebrovascular dysfunction during experimental cerebral malaria.
1/2021	Whole blood transfusion improves vascular integrity and increases survival in artemether-treated experimental cerebral malaria.
1/2019	L-arginine supplementation and thromboxane synthase inhibition increases cerebral blood flow in experimental cerebral malaria.
10/2018	Reversal of cerebrovascular constriction in experimental cerebral malaria by L-arginine.
3/2018	Perillyl alcohol exhibits in vitro inhibitory activity against Plasmodium falciparum and protects against experimental cerebral malaria.
10/2015	NO-Donor Dihydroartemisinin Derivatives as Multitarget Agents for the Treatment of Cerebral Malaria.
5/2015	From METS to malaria: RRx-001, a multi-faceted anticancer agent with activity in cerebral malaria.
11/2013	Transdermal glyceryl trinitrate as an effective adjunctive treatment with artemether for late-stage experimental cerebral malaria.
7/2013	A chronic scheme of cranial window preparation to study pial vascular reactivity in murine cerebral malaria.
4/2013	Slow and continuous delivery of a low dose of nimodipine improves survival and electrocardiogram parameters in rescue therapy of mice with experimental cerebral malaria.

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Leonardo J M Carvalho Research Topics

Disease

17	Cerebral Malaria 03/2021 - 01/2006
13	Infections 03/2021 - 02/2005
9	Malaria 01/2021 - 02/2005
5	Parasitemia 07/2020 - 02/2005
4	Inflammation (Inflammations) 03/2018 - 06/2011
3	Anemia 01/2021 - 01/2012
2	Hemorrhage 05/2011 - 03/2010
1	Coma (Comas) 01/2021
1	Babesiosis (Piroplasmosis) 07/2020
1	Hypoxia (Hypoxemia) 01/2019
1	Brain Ischemia (Cerebral Ischemia) 01/2019
1	Ischemia 01/2019
1	Necrosis 03/2018
1	Falciparum Malaria (Plasmodium falciparum Malaria) 01/2017
1	Glucosephosphate Dehydrogenase Deficiency 05/2015
1	Acute Disease 03/2015
1	Convalescence 03/2015
1	Hyperplasia 03/2015
1	Hypotension (Low Blood Pressure) 04/2013
1	Bradycardia 04/2013
1	Encephalitis (Encephalitis, Rasmussen) 06/2012
1	Communicable Diseases (Infectious Diseases) 12/2005

Drug/Important Bio-Agent (IBA)

8	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2019 - 05/2011
5	Artemether FDA Link 01/2021 - 03/2010
4	artemisinin (artemisinine)IBA 03/2021 - 05/2015
4	ArtesunateIBA 07/2020 - 04/2013
4	Antimalarials (Antimalarial Agents)IBA 01/2017 - 04/2013
4	VaccinesIBA 01/2017 - 02/2005
3	Mefloquine (Lariam)FDA LinkGeneric 07/2020 - 08/2013
3	Arginine (L-Arginine)FDA Link 01/2019 - 01/2012
2	perillyl alcoholIBA 03/2021 - 03/2018
2	CytokinesIBA 03/2018 - 04/2015
2	Interleukin-12 (IL 12)IBA 03/2018 - 03/2015
2	Interleukin-6 (Interleukin 6)IBA 03/2018 - 03/2015
2	Chloroquine (Aralen)FDA LinkGeneric 03/2015 - 08/2013
2	Nimodipine (Modus)FDA LinkGeneric 04/2013 - 03/2010
2	AntibodiesIBA 06/2011 - 02/2005
1	tafenoquineIBA 07/2020
1	8-aminoquinolineIBA 07/2020
1	ThromboxanesIBA 01/2019
1	InterleukinsIBA 03/2018
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 03/2018
1	InterferonsIBA 03/2018
1	Liposomes (Liposome)IBA 01/2017
1	Clodronic Acid (Clodronate)IBA 01/2017
1	1,2,5-oxadiazole 2-oxideIBA 10/2015
1	artenimol (dihydroartemisinin)IBA 10/2015
1	Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)IBA 05/2015
1	Heme (Haem)IBA 05/2015
1	Antineoplastic Agents (Antineoplastics)IBA 05/2015
1	RRx-001IBA 05/2015
1	Interleukin-2 (IL2)IBA 03/2015
1	hemozoinIBA 03/2015
1	Interleukin-10 (Interleukin 10)IBA 03/2015
1	Hemoglobins (Hemoglobin)IBA 11/2013
1	Nitroglycerin (Dynamite)FDA LinkGeneric 11/2013
1	Quinine (Quinson)FDA Link 08/2013
1	Nitric Oxide Synthase (NO Synthase)IBA 01/2013
1	dipropylenetriamine-NONOateIBA 06/2012
1	S-NitrosoglutathioneIBA 06/2012
1	Glutathione (Reduced Glutathione)IBA 06/2012
1	sapropterin (tetrahydrobiopterin)FDA Link 01/2012
1	Sodium NitriteIBA 01/2012
1	Sildenafil Citrate (Viagra)FDA Link 01/2012
1	AlbuminsIBA 06/2011
1	Fluorescein-5-isothiocyanate (FITC)IBA 06/2011
1	P-SelectinIBA 06/2011
1	Amodiaquine (Camoquin)FDA Link 05/2011
1	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 03/2010
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2006
1	Dehydroepiandrosterone (DHEA)IBA 01/2006
1	Estradiol (Delestrogen)FDA LinkGeneric 01/2006
1	Proteins (Proteins, Gene)FDA Link 12/2005
1	B-Lymphocyte Epitopes (B-Cell Epitope)IBA 12/2005
1	Peptides (Polypeptides)IBA 12/2005
1	Immunoglobulin G (IgG)IBA 12/2005
1	Malaria VaccinesIBA 12/2005
1	Glutamic Acid (Glutamate)FDA Link 12/2005
1	Subunit VaccinesIBA 12/2005
1	Monatide (IMS 3015)IBA 02/2005
1	aluminum sulfate (alum)IBA 02/2005

Therapy/Procedure

6	Therapeutics 03/2021 - 01/2012
1	Blood Transfusion (Blood Transfusions) 01/2021
1	Intranasal Administration 03/2018
1	Splenectomy 01/2017
1	Aftercare (After-Treatment) 03/2015
1	Craniotomy 07/2013
1	Injections 01/2012
1	Castration 01/2006